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Preprint: Dissecting White Matter Pathways: A Neuroanatomical Approach

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Dissecting white matter pathways
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The brain is the most magnificent structure, and we are only at the cusp of unravelling some of its complexity. Neuroanatomy is the best tool for mapping the brain’s structural complexity. As such, neuroanatomy is not just an academic exercise; it serves our fundamental understanding of the neurobiology of cognition and improves clinical practice.

A deepened anatomical understanding has advanced our conceptual grasp of the evolution of the brain, interindividual variability of cognition in health and disease, and the conceptual shift toward the emergence of cognition. For the past 20 years, diffusion imaging tractography has dramatically facilitated these advances by enabling the study of the delicate networks that orchestrate brain processes (for review, see (Thiebaut de Schotten and Forkel, 2022).

When analysing tractography data, several steps are consistent across all studied populations and brain states (health/disease). We will discuss various considerations for dissections across populations and give practical tips on common pitfalls and features to improve the visualisation of the dissections. We briefly discuss specific considerations for manual dissections in non-human primates. Lastly, we provide an atlas of regions of interest (ROIs) for the most commonly delineated white matter connections.

Cite as:

Forkel, S., Bortolami, C., Dulyan, L., Barrett, R. L., & Beyh, A. Dissecting white matter pathways: A neuroanatomical approach. Retrieved from

In Handbook of Diffusion Imaging. (Dell’Acqua & Leemanns, Eds), forthcoming

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